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Name:Terlipressin

Catalog No.:B0377

Terlipressin

Chemical Properties

Synonyms: H-Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2(Cys and Cys bridge)
Cas No.: 14636-12-5 Purity Limit: ≥99.5%
Molecular Weight: 1227.37 Formula: C52H74N16O15S2
Storage: -20℃ Solubility:

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Description

Terlipressin is a new synthetic long-acting vasopressin preparation. Its chemical name is triglyceride lysine vasopressin. It belongs to a precursor drug. It is inactive. After aminopeptidase is used in vivo to remove the three glycyl residues at its N-terminal, it releases the active lysine vasopressin slowly. It is this "slow release" mechanism that allows smooth muscle contraction to last up to 10 hours after a single dose, while vasopressin activity can only last 20-40 minutes at the same dose. On the other hand, because of the slow enzymatic hydrolysis rate, the circulating lysine vasopressin can not reach the toxic level, so the use of terlipressin is relatively safe.The drug  is used for the treatment of bleeding of gastrointestinal tract and urogenital system, such as esophageal varices, gastric and duodenal ulcers, functional and other causes of uterine bleeding, production and/or abortion, etc. It is used for the treatment of bleeding after operation, especially in the abdominal and pelvic areas; the Bureau of gynecological surgery. Department application, such as in the cervix.

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